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2 edition of Interaction of cholesterol with sphingomyelins and phosphatidylcholines in model membranes found in the catalog.

Interaction of cholesterol with sphingomyelins and phosphatidylcholines in model membranes

Peter Mattjus

Interaction of cholesterol with sphingomyelins and phosphatidylcholines in model membranes

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Published by Åbo Akademis Förlag in Åbo .
Written in English

    Subjects:
  • Cholesterol -- Metabolism,
  • Cholesterol -- Physiological effect,
  • Cholesterol oxides,
  • Cholesterol oxides -- Physiologica effect

  • Edition Notes

    Includes bibliographical references.

    Statementby Peter Mattjus.
    SeriesActa Academiae Aboensis. Ser. B, Mathematica et physica = -- Matematik, naturvetenskaper, teknik -- v. 56, nr 1, Acta Academiae Aboensis -- v. 56, nr 1.
    Classifications
    LC ClassificationsQP752.C5 M38 1996"
    The Physical Object
    Pagination37 p. :
    Number of Pages37
    ID Numbers
    Open LibraryOL20172404M
    ISBN 10952961666X

    The role of cholesterol-sphingomyelin membrane nanodomains in the stability of intercellular membrane nanotubes Maruša Lokar1,*, Doron Kabaso1,2,*, Nataša Resnik3, Kristina Sepcic5, Veronika Kralj-Iglic4,6, Peter Veranic3, Robert Zorec2, Aleš Iglic1,6 1Laboratory of Biophysics, Faculty of Electrical Engineering, 2Laboratory of Neuroendocrinology-Molecular Cell . Interpretation: The linkages which involve a phosphate residue in the given block diagram of glycerophospholipid have to be predicted. Concept introduction: The lipids based on glycerol are called glycerophospholipids. They are basically made up of two fatty acids, a phosphate group which is esterified to glycerol and an alcohol group which is esterified to the phosphate group.   Diets enriched with sphingolipids may improve blood lipid profiles. Studies in animals have shown reductions in cholesterol absorption and alterations in blood lipids after treatment with sphingomyelin (SM). However, minimal information exists on effect of SM on cholesterol absorption and metabolism in humans. The objective was to assess the effect of Cited by: (BQ) Part 1 book Encyclopedia of physical science and technology Biochemistry has contents: Glycoconjugates and carbohydrates, ion transport across biological membranes, lipoprotein cholesterol metabolism, membrane structure. energy needed P1: FYD Revised.


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Interaction of cholesterol with sphingomyelins and phosphatidylcholines in model membranes by Peter Mattjus Download PDF EPUB FB2

When the interaction of cholesterol with phosphatidylcholines was measured in monolayer membranes using cholesterol oxidase as a probe, the oxidation susceptibility of cholesterol was observed to be lowest in phosphatidylcholine monolayers having acyl chain lengths between andand higher in membranes with phosphatidylcholines having Cited by: In this study we have synthesized sphingomyelins (SM) and phosphatidylcholines (PC) with amide-linked or sn-2 linked acyl chains with lengths from 14 to 24 purpose was to examine how the chain length and degree of unsaturation affected the interaction of cholesterol with these phospholipids in model membrane by: 1.

Chem Phys Lipids. Nov;33(4) Phosphatidylcholine and cholesterol interactions in model membranes. Guyer W, Bloch K. Various phosphatidylcholines differing either in the stereochemistry around their chiral center or in the position of a cis double bond along the acyl chains were synthesized in order to study critical contact regions in the phospholipid molecule Cited by: Thus, we have studied doxorubicin’s interaction with model membranes in a cholesterol rich, ordered environment and in liquid-disordered cholesterol poor environment.

Organization and interaction of cholesterol and phosphatidylcholine in model bilayer membranes. Hyslop PA(1), Morel B, Sauerheber RD. Author information: (1)Department of Central Nervous System Pharmacology, Lilly Research Laboratories, Indianapolis, Indiana Cited by: Sphingomyelin (SPH, ˌsfɪŋɡoˈmaɪəlɪn) is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath that surrounds some nerve cell usually consists of phosphocholine and ceramide, or a phosphoethanolamine head group; therefore, sphingomyelins can also be classified as sphingophospholipids.

In humans, SPH represents. In fact, using model membranes, it has been demonstrated that cholesterol interacts more favorably with sphingomyelin than with phosphatidylcholine [32].

Figure 3. Cholesterol-cholesterol interactions. In model membranes, two cholesterol molecules can form a tail-to-tail (A) or a face-to-face (B) complex.

In the latter case, the self-recognition properties of cholesterol can induce the dimerization of membrane receptors (C), as demonstrated for G-protein-coupled receptors with 7-TM by: Interactions ofN-Stearoyl Sphingomyelinwith Cholesterol and Dipalmitoylphosphatidylcholine in Bilayer Membranes P.

Maulik and G. Shipley Departments of Biophysics and Biochemistry, Boston University School of Medicine, Centerfor Advanced Biomedical Research, Boston, Massachusetts USA.

Interaction of cholesterol with sphingomyelin in mixed membranes containing phosphatidylcholine, studied by spin-label ESR and IR spectroscopies. A possible stabilization of gel-phase sphingolipid domains by by: Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup.

They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from which they are mechanically or chemically extracted using are also a member of the lecithin group of yellow.

Mattjus, P., Bittman, R., and Slotte, J. P.,Molecular interaction and lateral domain formation in monolayers containing cholesterol and phosphatidylcholines with acyl-or alkyl-linked C16 chains, Langmuir – CrossRef Google ScholarCited by: However, for the higher applied pressures, cholesterol reduces the interbilayer separation distance by an amount that depends on the cholesterol concentration in the bilayer.

For example, the incorporation of equimolar cholesterol reduces the distance between bilayers by as much as 6 A at an applied pressure of atm. Cholesterol plays a vital role in determining the physiochemical properties of cell membranes. However, the detailed nature of cholesterol–lipid interactions is a subject of ongoing debate.

Ex-isting conceptual models, including the Condensed Complex Model, the Superlattice Model, and the Umbrella Model, identify. ABSTRACT The interaction between cholesterol and phospholipids in bilayer membranes is important for the formation and maintenance of membrane structure and function.

However, cholesterol does not interact favorably with all types of phospholipids and, for example, prefers more ordered sphingomyelins (SMs) over phosphatidylcholines (PCs).

The membrane enclosing a typical animal cell is a phospholipid bilayer with embedded cholesterol and protein molecules.

Short oligosaccharide chains are attached to the outer surface. In the bilayer interior, the hydrophobic tails (that is, the fatty acid portions of lipid molecules) interact by means of dispersion forces.

Reverse cholesterol transport that removes cholesterol from peripheral cells and returns it to the liver is carried out by _____.

HDL The key to the cell's internalization of LDL is the interaction between the receptors and _____. Diffusion of cholesterol analogues compared with phospholipid analogues in model membranes.

Previous reports suggested fast diffusion of TF-Chol (≈3 μm 2 /s) in the plasma membrane of live cells (18, 19).To tackle how cholesterol moves compared with phospho- and sphingolipids in the cell membrane systematically, we used simple artificial model Cited by: 3.

On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a.

Organization and interaction of cholesterol and phosphatidylcholine in model bilayer membranes. Biochemis Crossref, Medline, Google Scholar; Koval M., Pagano R. Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured.

T1 - The role of the phospholipid sphingomyelin in heart disease. AU - Chatterjee, Subroto B. AU - Kolmakova, Antonina.

AU - Miller, Michael. PY - /3. Y1 - /3. N2 - Sphingomyelin (SM) is an integral component of mammalian cell membranes and by:   Sphingomyelins (SMs) are among the most common sphingolipids in many mammalian cells and tissues, especially in the membranous myelin sheath that surrounds nerve cell axons.

3 SMs have significant structural and functional roles in the cell such as creating unique lateral structures (lipid rafts and ordered domains) in membranes, binding to and Author: Petros Kikas, George Chalikias, Dimitrios Tziakas. Arguably the most notable year in the study of biological membranes was Not only the archetypal fluid mosaic model of Singer and Nicolson [] was published inbut Mark Bretscher provided the first report of partial lipid asymmetry in membranes [2,3].Remarkably, only a year later, quantitative analysis of the asymmetric lipid distribution in various cell types, Cited by: Monolayers composed of bacterial phospholipids were used as model membranes to study interactions of the naturally occurring phenolic compounds 2,5-dihydroxybenzaldehyde and 2-hydroxymethoxybenzaldehyde, and the plant essential oil compounds carvacrol, cinnamaldehyde, and geraniol, previously found to be active against both Gram-positive and Cited by: from membranes were enriched in (glyco)sphingolipids and cholesterol (chol) and depleted in phosphatidylcholines (PC) (Simons and Ikonen, ).

The natural lipids with highest main transition temperature (T m) in membranes are (glyco)-sphingolipids, some of them having T m much higher than C (e.g., cerebrosides (Marsh, )) but in.

Cholesterol (CHOL), the main sterol component of eukaryotic membranes, plays an important role in membranes as a modulator of physical and functional properties of lipid bilayers (Yeagle ). CHOL is distributed heterogeneously among cellular membranes.

Its molar fraction is lowest. Abstract. We examined the effects of reduction of sphingomyelin level on cholesterol behavior in cells using 2 types of Chinese hamster ovary cell mutants deficient in sphingomyelin synthesis: LY-A strain defective in intracellular trafficking of ceramide for sphingomyelin synthesis, and LY-B strain defective in the enzyme catalyzing the initial step of.

Abstract. Spontaneous insertion of membrane proteins into liposomes formed from Escherichia coli polar phospholipids is blocked by diacylglycerol (DAG) at a physiological level.

We found that cholesterol also blocks this spontaneous insertion, although a much larger amount is necessary for sufficient by: 3. Pulsed field gradient (pfg)-NMR measurements of the lipid lateral diffusion coefficients in several macroscopically aligned bilayer systems were summarized from previous and new studies.

The aim was to carry out a comparison of the translational dynamics for bilayers with various mixtures of l,2-dioleoyl- sn -glycerophosphocholine (DOPC), l,2-dipalmitoyl- sn. Hederacoside C, α-Hederin: Triterpene Saponins from Ivy with Differences in Membrane Toxicity Besides digitonin, a variety of further saponins was studied with regard to interactions with cholesterol in membranes and resulting permeabilizing effects [], [], [].Böttger et al.

[] also found a correlation between a perturbing biological membrane and surface activity for α-hederin and Cited by:   The particularly favorable fit between the “CARC-like” TM4 segment in the γ subunit of the human nAChR ( R VC F LAM L ) and cholesterol is remarkable, with an energy of interaction of about − 60 kJ mol − 1, i.e.

∼60% of the total energy of interaction of the entire γ subunit, which displays the highest affinity for Cited by: 1. Cholesterol is a steroid molecule with an OH group polar head, non-polar steroid rings and an hydrocarbon tail. Cholesterol Affecting the Membrane It impacts the fluidity of the membrane because the structures are extremely rigid.

A combination of Langmuir trough monolayer techniques, vesicle permeability and binding assays, and in situ atomic force microscopy (AFM) were used to directly monitor the interaction of a model, synthetic htt peptide and a full-length htt-exon1 recombinant protein with model membranes comprised of total brain lipid extract (TBLE) and varying Cited by: 3.

Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT).Cited by: As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells.

It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide. Enter search terms. Keep search filters New search.

Advanced search. A year-old researcher argues that, contrary to decades of clinical assumptions and advice to patients, dietary cholesterol is good for your heart -.

The Chopra Foundation’s Mission is to participate with individuals and organizations in creating a critical mass for a peaceful, just, sustainable, and healthy world through scientifically and experientially exploring non-dual consciousness as the ground of existence and applying this understanding in the enhancement of health, business, leadership and conflict resolution.

Also, the liquid-disordered matrix in cell membranes might be less permeable and more tightly packed than a simple two-component unsaturated phospholipid-cholesterol model membrane. Israelachvili (36) postulated early on that lipid complexity is required to fill the holes the integral proteins create in membrane by:   Studies have shown that plasma high density lipoprotein cholesterol levels are negatively correlated with the development of atherosclerosis, whereas epidemiological studies have also shown that plasma sphingomyelin level is an independent risk factor for atherosclerosis.

To evaluate the relationship between cellular sphingomyelin level and cholesterol metabolism, Cited by:. Comparison of the interaction of tomatine with mixed monolayers containing phospholipid, egg sphingomyelin, and sterols. Biochim Biophys Acta ; ; 99 Ramstedt B, Slotte JP.

Interaction of cholesterol with sphingomyelins and acyl-chain-matched phosphatidylcholines: a comparative study of the effect of the chain length. Biophys Cited by: Resolution of Sphingomyelins in Complex Lipid Extracts by Differential Ion Mobility Spectrometry (DMS) SelexION™ Technology Paul RS Baker, Baljit K Ubhi, and J Larry Campbell AB SCIEX A significant challenge in the field of lipidomics is the extensive isobaric and isomeric overlap of different lipid molecular species.

Phosphatidylcholine (PC) 3 plays an important role in intestinal lipid absorption by enhancing micellar lipid solubility and providing the surface coat PC for the formation of chylomicrons.

Although an adequate supply of PC from bile or diets is necessary to support the normal rate of fat absorption, numerous in vitro studies have shown that PC inhibits Cited by: